Prospective Study of the Regeneration of B cells after Allogeneic Hematopoietic Stem cell Transplantation

Abstract

B cells reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different parameters such as patient age, underlying disease, and graft versus host disease (GVHD) and its therapy. This study was carried in the period from October 2009 to October 2010.we carried out a prospective analysis of different B-cell subsets regeneration in 14 consecutive HSCT recipients before and during the first year post transplantation by measuring CD19+ and CD20+ B-cell subsets for each patient. Data were presented as minimum, maximum and median using Excel spread data sheath. Gradual increasing of the absolute count CD19+ and CD20+ B-cells subsets was demonstrated. Frequencies of B-cells were significantly higher in patients without chronic GVHD. B-cells reconstitution after HSCT is changeable and affected by many factors, especially chronic graft versus host disease.