The Role of Telomeres and Telomerase in Human Aging and Aging Associated Diseases

Abstract

An expanding confirmation for the existence of an imperative association between telomeres and cellular aging. With each cell division ordinary human cells dynamically lose telomeres until many telomeres become uncapped driving the cells to risk, although cells have short telomeres but continuous to dividing causing critical cell passing to cell death (apoptosis) and strong genomic variability. Infrequently a human cells get away of that risk, these cells virtually express the ribonucleoprotein, telomerase, which thought of as a component to adequate down the rate genomic instability due to damaged telomeres. This review will address the role of telomeres and telomerase in human aging and aging associated diseases.